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KMID : 1189320160100050964
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Asian Spine Journal
2016 Volume.10 No. 5 p.964 ~ p.971
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Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of Intervertebral Disc Degeneration Susceptibility: Meta-Analysis
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Nong Lu Ming
Huang Yong Jing
Zhao Shu Jie
Xu Nan Wei
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Abstract
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Several studies have evaluated the association between vitamin D receptor, matrix metalloproteinase 3 (MMP-3) polymorphisms and the risk of intervertebral disc degeneration susceptibility. The findings were inconsistent. This meta-analysis aimed to systematically assess the association between vitamin D receptor, MMP-3 polymorphisms and the risk of intervertebral disc degeneration susceptibility. A search of various databases was done covering all papers published until December 31th, 2014. Eight, 4, 3 studies were finally included that addressed the risk of intervertebral disc degeneration susceptibility and vitamin D receptor FokI (rs2228570), ApaI (rs7975232), and MMP-3 (rs731236) polymorphisms, respectively. FokI (f vs. F: summary odds ratio [OR], 1.13; 95% confidence interval [CI], 0.76?1.69; ff vs. FF: OR, 1.02; 95% CI, 0.59?1.77; ff vs. Ff/FF: OR, 1.05; 95% CI, 0.70?1.58), ApaI (a vs. A: OR, 0.73; 95% CI, 0.45?1.19; aa vs. AA: OR, 0.53; 95% CI, 0.22?1.25 p=0.14; aa vs. AA/Aa: OR, 0.69; 95% CI, 0.53?0.89) in the vitamin D receptor gene and MMP3 polymorphisms (5A vs. 6A: OR, 1.92; 95% CI, 0.77?4.80; 5A5A vs. 6A6A: OR, 2.17; 95% CI, 0.75?6.24; 5A5A vs. 5A6A/6A6A: OR, 1.58; 95% CI, 0.72?3.44) were not obviously associated with risk of intervertebral disc degeneration susceptibility. FokI, ApaI polymorphisms in the vitamin D receptor gene and MMP-3 polymorphism are not obvious risk factors for intervertebral disc degeneration susceptibility.
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KEYWORD
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Vitamin D receptor, Matrix metalloproteinase-3, Polymorphism, Meta-analysis
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